Evaluation of BNP in Patients With Severe Acute Respiratory Failure Requiring Non Invasive Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.
详细描述
The aim of the study is to evaluate in patients with severe acute respiratory failure requiring non invasive mechanical ventilation BNP levels at admission and during the following 24 hours during non invasive mechanical ventilation (Non Invasive Positive Pressure Ventilation or Continuous positive airway pressure).
Because in patients affected by acute respiratory failure it is often difficult to distinguish if the disease precipitating the respiratory failure is a cardiac disease or a lung disease, aim of the present study is to evaluate the discriminating role that BNP could have in this group of patients; evaluation will be completed, once obtained clinical stabilisation, with an echocardiography and respiratory functional test.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe respiratory distress (use of respiratory accessory muscles);
- •Respiratory rate > 25 per minute;
- •Respiratory acidosis (pH < 7.35 and PaCO2 > 45 mmHg);
- •PaO2/FiO2 < 250
排除标准
- •Age < 18 years;
- •Facial deformities;
- •Pneumothorax;
- •Shock or systolic arterial pressure below 90 mmHg with amine infusion;
- •Life-threatening arrhythmias;
- •Need for immediate endotracheal intubation (PaO2/FiO2 < 100 with FiO2 100%, respiratory rate < 10, GCS < 8);
- •Lack of co-operation from the patient;
- •Recent esophageal-gastric surgery;
- •Inability to clear secretions;
- •Drugs that may interfere with BNP secretion;
- •Severe obesity;
- •Hepatic cirrhosis with ascitis;
- •Endocrine disease.