The Effect of a High Fat Compared to a High Sugar Diet on Liver Fat Accumulation and Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Change in liver fat content
研究概览
简要总结
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the world. It is currently unclear why fat starts to accumulate in the liver, although both the amount and type of food consumed have been implicated. The majority of studies that have investigated the effects of dietary fat or sugar on liver fat have fed volunteers excess calories, which are known to increase liver fat. The effect of specific dietary components, when consumed as part of a diet not containing excess calories, on liver fat accumulation remains unclear.
详细描述
This research aims to investigate the role excessive consumption of specific macronutrients may play in the development of NAFLD. This will be achieved by subjecting participants to two specific dietary interventions (high-fat, low-carbohydrate and low-fat, high-carbohydrate) in a randomized, crossover research design. Liver fat content, and whole-body and hepatic fasting and postprandial lipid metabolism will be assessed before and after the specific dietary interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
盲法说明
PI,and research assistants undertaking measurements will be blinded to the dietary intervention the participant is undertaking.
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is willing and able to give informed consent for participation in the study.
- •BMI >25 <35kg/m2
- •No medical condition or relevant drug therapy known to affect liver, lipid or glucose metabolism
排除标准
- •Age <30 or >65 years
- •Body mass index <25 or >35kg/m2
- •A blood haemoglobin <120mg/dL
- •Any metabolic condition or relevant drug therapy
- •People who do not tolerate fructose
- •History of alcoholism or a greater than recommended alcohol intake
- •Pregnant or nursing mothers
- •Women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months
- •History of severe claustrophobia
- •Presence of metallic implants, pacemaker
- •Haemorrhagic disorders
- •Anticoagulant treatment
结局指标
主要结局
Change in liver fat content
时间窗: Before, and within 7 days after completion of each dietary intervention
Investigators will measure the change in liver fat content after each of the 4 week intervention diets by magnetic resonance imaging/spectroscopy (MRI/S).
次要结局
- Change in hepatic fatty acid partitioning(Within 7 days after completion of each dietary intervention)
- Change in plasma metabolite concentrations(Before, and within 7 days after completion of each dietary intervention.)
- Change in whole-body fatty acid oxidation(Within 7 days after completion of each dietary intervention)