跳至主要内容
临床试验/CTRI/2023/06/053840
CTRI/2023/06/053840进行中(未招募)不适用

Exploring the association between sudden limb exposure to temperature alteration following an exertion with varicose vein & chronic venous disease - A case control study

Central Council for Research in Ayurvedic Sciences1 个研究点 分布在 1 个国家目标入组 394 人开始时间: 2023年6月21日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
394
试验地点
1
主要终点
Association between sudden limb exposure to temperature alteration following an exertion with varicose vein

研究概览

简要总结

The pathological stagesof Chronic venous disease have been evaluated with a range of pathologicalconditions in Ayurveda such as Siragranthi (venous abnormalities), Raktavarita vÄta (disorders of vÄta occludedby rakta~ blood),Apana Vaigunya (vitiatedapÄnavÄyu),Arsha (hemorrhoids), Vata Rakta (rheumatism due to rakta), Kushtha (integumentary disease), and Dushta Vrana(putrified wound)depending upon the presentations of the patient.

Siragranthi mentioned in ayurvedic texts ideally explains thevarious venous abnormalities and specifically varicose veins. There are variousrisk factors hypothesised for the development of varicose veins such asobesity, prolonged standing & sitting, constipation and pregnancy1.But no theory has been proposed as the causative factor for its structuralmodification of veins and its complications. Astanga Hrdaya hasspecifically mentioned that a person after any type of exertion like walking orexercise when suddenly washes or dips his legs in water will affect the sirawhich further undergoes structural changes and results in siragranthi(cyst like venous abnormalities  ~varicose veins)2. It can be understood that when the veins aredilated during exertion will get contracted by sudden exposure of cold water.Continuous practice of this will lead to loss of elasticity of venous wallswhich results in venous wall collapse. This cause can be extrapolated tocurrent scenario as a sudden limb exposure to temperature alteration following an exertion. Thiscase control study is aimed to study this association with the development ofvaricose vein and subsequently chronic venous disease.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 75.00 Year(s)(—)
性别
All

入选标准

  • •Inclusion Criteria for Case: 1.Patients over 18 years with diagnosed chronic venous disease for a duration of less than or equal to 5 years.
  • •2.Patient who are able to recollect and tell the details of exposure and other questions asked by the investigators.
  • •Inclusion Criteria for Control: 1.Patients or healthy volunteers (attenders) satisfying all eligibility criteria defined for cases without chronic venous disease.
  • •2.Patients with different musculoskeletal or neurological diseases diagnosed in a time period less than or equal to 5 years.

排除标准

  • •Patients with arterial disease, pregnant women, lactating mothers, terminally ill patients, patients with memory impairment and those unwilling to participate were excluded.

结局指标

主要结局

Association between sudden limb exposure to temperature alteration following an exertion with varicose vein

时间窗: Base line

and chronic venous disease.

时间窗: Base line

次要结局

  • association of various characteristics & risk factors with varicose vein and chronic venous disease.(base line)

研究者

申办方类型
Research institution

研究点 (1)

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