CTRI/2024/06/069541尚未招募2 期
Effect of Metformin therapy on progression of Autosomal Dominant Polycystic Kidney Disease: an open label 2: 1 randomized controlled trial - NI
IPGMER and SSKM hospital0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Patients with ADPKD defined as per case definition between 18-65 years
- •2. eGFR > 45 ml/min/1.73 m2 as per CKD EPI 2021 equation.
- •3. Typical or Class 1 ADPKD on MRI.
排除标准
- •1. Patients with Diabetes mellitus.
- •2. Patients with liver disease (elevation of liver enzymes >2 times the baseline).
- •3. Females who were pregnant or breast feeding or unwilling to use contraception.
- •4. Congestive heart failure,
- •5. Unable to undergo MR imaging.
- •6. Subjects those were taking medications that interact with metformin like digoxin,
- •quinidine, cimetidine.
- •7. Known hypersensitivity to metformin and its derivatives.
- •8. Psychiatric disorders and any condition that might prevent full comprehension of the
- •purposes and risks of the study.
- •9. HIV, HBV, HCV infection.
- •10. Urinary tract obstruction.
- •11. Atypical Type 2 ADPKD on MRI
研究者
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