Effects of Japanese herbal medicine saikokeishikankyoto (SKK) on PTSD - Effects of saikokeishikankyoto (SKK) on PTSD

This randomized, observer-blinded, controlled trial examined the efficacy and safety of the traditional Japanese herbal formula saikokeishikankyoto (SKK) in the treatment of PTSD among survivors of this disaster. Forty-three participants with an Impact of Event Scale-Revised (IES-R) score over 25 were randomized into SKK and control groups. The primary endpoint was the change in IES-R scores from baseline till after 2 weeks of treatment. Intergroup statistical comparisons were performed. The magnitude of changes in total IES-R scores differed significantly between the two groups . Post hoc analysis showed that the total IES-R score improved significantly in the SKK group from 49.6 to 25.5 (P < 0.001). Subscale scores improved significantly in the SKK group (avoidance, ; hyperarousal, ; intrusion, ). Two-week treatment with SKK significantly improved IES-R scores among PTSD patients. This traditional medicine may be a valid choice for the treatment of psychological and physical symptoms in PTSD patients.