Renal Function Evaluation in an Ultra Endurance Race: On the Interest of Monitoring Specific Biomarkers to Asses Renal Risk.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Glomerular filtration rate
研究概览
简要总结
During ultra endurance events, athletes experience extreme physical and mental demands, sometimes at the limits of the adaptive response to human physiology. This is particularly true for the renal function, and some evidence for acute renal failure has already been shown, sometimes leading to dialysis. However, the precise mechanisms involved in acute renal failure in such ultra endurance races are not clearly elucidated.
The aim of our study is to estimate glomerular filtration rate from serum and urinary creatinine and cystitin C at the beginning and at the end of a 110 km ultra endurance race. Our hypothesis is that during the ultra endurance race, renal function may be injured, with a risk for the athlete.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: At least 20 years old
- •Athlete that is officially registered to the 110 km race (INFERNAL Trail des Vosges)
- •Athlete informed by a member (MD) of the Medical Staff of the race.
- •Athlete that gives and signes the informed consent to the research protocol
排除标准
- •Athlete with a known disease that needs the following medications:
- •Medications influencing the renin-angiotensin-aldosteron system (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosteron receptor blockers)
- •Diuretic drugs
- •Anticoagulant drugs
- •Non-steroidal anti-inflammatory drugs
- •Athlete with a known thyroid disease (because of the influence on the serum cystatin level)
- •Athlete with a know renal disease
- •Athlete with a know inflammatory disease
结局指标
主要结局
Glomerular filtration rate
时间窗: 30 minutes at baseline (09.07.2017), and 30 minutes at the end of the 110 km race (2 or 3 days after baseline)
The glomerular filtration rate will be calculated from the serum and urinary creatinine and cystatin C dosage
次要结局
未报告次要终点