NCT01782625已完成不适用
Hypercapnia: Cognitive Effects and Monitoring
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Is cognitive ability different while resting versus compared to cognitive ability while diving, breathing different gas mixtures and while exercising?
研究概览
简要总结
The investigators will simulate the conditions of a working, helmeted diver by using exercising, "head out" immersed subjects to test the following hypotheses:
- An algorithm can be developed which predicts cognitive performance in immersed exercising divers, based on the exhaled carbon dioxide (PETCO2) and the diver's inspired partial pressures of oxygen and nitrogen (PIO2 and PIN2).
- PETCO2 using mass spectrometry is an accurate estimate of arterial carbon dioxide (PaCO2) at rest and during immersed exercise and can be used as a PaCO2 surrogate at levels exceeding 50 mmHg and depths up to 158 fsw (gas density 6.4 g/l, similar to 165 fsw density of 6.8 g/l).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age greater than 18,
- •age less than 50
排除标准
- •cardiac disease,
- •inability to pedal a bicycle ergometer,
- •inability to perform vigorous exercise
结局指标
主要结局
Is cognitive ability different while resting versus compared to cognitive ability while diving, breathing different gas mixtures and while exercising?
时间窗: pre-dive to dive to post-dive (approximately 2 hours)
Subjects will undergo computerized cognitive testing before, during and after a simulated dive in the Duke Hyperbaric Chamber. Different exercise conditions (rest or exercise) and different breathing gas mixtures (added carbon dioxide or not)will be assessed and compared to the pre-dive conditions.
次要结局
- How does exhaled (end tidal) carbon dioxide compare with arterial carbon dioxide?(pre-dive to dive to post dive (approximately 2 hours))
研究者
研究点 (2)
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