Investigation of Clinical, Cognitive and Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 84
- 试验地点
- 2
- 主要终点
- Index of affect
研究概览
简要总结
The current diagnostic criteria for schizophrenia and other psychotic disorders are relatively broad and lack precision. Therefore, distinct diseases may be grouped together under the same diagnostic category, although these diseases may differ according to their clinical expression, prognosis and perhaps their physiopathological causes.
We think that identifying subforms of psychotic disorders that are more homogeneous will better enable to understand their respective physiopathological causes and find personalized treatments.
This study will compare two subforms of psychotic disorders that have been clinically distinguished in the 1970s. These phenotypes have however not been validated yet using scientific investigations.
Using clinical assessments, cognitive evaluations and neurophysiological measures (fMRI) investigating the domains of affect and psychomotoricity , we expect that these two subforms will differ on their clinical, cognitive and neurophysiological characteristics, namely: hebephrenia will be associated with deficits on the affect markers , and respect psychomotoricity (catatonia scales, tests assessing movement planification) whereas the opposite pattern will be observed for periodic catatonia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for both patients and controls
- •male or female willing to participate and who have signed up the legal document
- •under the protection of health insurance for patients only
- •schizophrenia or schizo-affective disorder according to the DSM-5 criteria
- •periodic catatonia or hebephrenia accordin to WKL classification
- •clinically stable for at least 2 months
- •in or out patients for controls only
- •no psychiatric history
排除标准
- •for both patients and controls
- •current severe or unstable somatic illness
- •neurological history (epilepsia, brain injury, brain surgery…)
- •current substance use disorder (DSM-5)
- •current major depressive disorder (DSM-5)
- •mental retardation (IQ < 70)
- •pregnancy, breast feeding
- •current legal control
- •contra-indication for fMRI for controls only psychotropic intake during the last 3 weeks
结局指标
主要结局
Index of affect
时间窗: 6 months after inclusion
Compare two groups of markers relating respectively to affectivity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation
Index of psychomotoricity
时间窗: 6 months after inclusion
Compare two groups of markers relating to psychomotricity in two subforms of schizophrenia: periodic catatonia and hebephrenia in order to highlight a possible double dissociation
次要结局
未报告次要终点