跳至主要内容
临床试验/NCT05040620
NCT05040620Unknown1 期

Effectiveness of Olive Oil Local Application in Decreasing the Period of Alignment Phase in Non Extraction Orthodontic Patients. A Randomized Controlled Clinical Trial.

Minia University1 个研究点 分布在 1 个国家目标入组 110 人开始时间: 2020年1月1日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
1 期
发起方
入组人数
110
试验地点
1
主要终点
The duration of orthodontic teeth aligning using Little irregualrity index

研究概览

简要总结

The large body of evidence supports the chemotherapeutic potential of substances found in Olive Oil (OO), acting on different sides, such as inflammation, oxidative damage, and even epigenetic modulation. The consumption of OO should be suggested in a healthy diet instead of other types of oils. It looks worthy, to determine the effect of local application of Olive Oil in decreasing the friction between brackets and wires during orthodontic treatment.

详细描述

During the orthodontic treatment, the friction between the bracket and the arch-wire could prevent the action of forces required for a particular tooth movement. Studies demonstrated that approximately 12 to 60% of the force used to move a tooth is dissipated in the form of friction. Consequently, a delay could occur in the biological response to orthodontic movement. The most important factors that may have an impact on friction are; the composition of the bracket, the arch-wire alloy, the cross-sectional size of the arch-wire, the type of ligation system and the surface roughness of the bracket-archwire assembly.

In addition to the factors related to the orthodontic appliances, saliva is considered to be a biological variable associated with friction, as it acts as a lubricant during sliding mechanics.This fact should be taken into account in laboratory studies that aim to evaluate the performance of the archwire-bracket combinations. However, in the majority of the research studies, the friction test has been conducted without the use of any lubricant, which does not represent the clinical reality where there is saliva introduced during the movement of the arch-wire on the bracket. To remedy this situation, distilled water has been used as a lubricant. Although in this case the test is conducted in the presence of a lubricant, water does not have the lubricating ability of natural human saliva.

It is well known that oil is a well-known lubricant. But how we can use it to decrease friction between brackets and wires? and which type of oil we can use safely in patient mouth? Olive oil (OO) (Olea europaea, Oleaceae) is a fundamental component of the Mediterranean Diet; it is a mix of fatty acids such as oleic and linoleic acid, secoiridoids (oleuropein and oleocanthal), simple phenols (tyrosol and hydroxytyrosol), lignans (pinoresinol), flavonoids (apigenin), hydrocarbons (squalene), triterpenes (maslinic acid), and phytosterols (β-sitosterol).

The large body of evidence supports the chemotherapeutic potential of substances found in OO, acting on different sides, such as inflammation, oxidative damage, and even epigenetic modulation. The consumption of OO should be suggested in a healthy diet instead of other types of oils. It looks worthy, to determine the effect of local application of Olive Oil in decreasing the friction between brackets and wires during orthodontic treatment.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

入排标准

年龄范围
15 Years 至 20 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • The age of patients ranges from 15-20 years old.
  • Mild to moderate dental irregularity requiring non-extraction treatment.
  • Presence of all the permanent teeth at least up to the first molars.
  • Good oral hygiene, and periodontal health.

排除标准

  • Patients require orthognathic surgery to correct skeletal discrepancies.
  • patients who are taking medications, like NSAIDs or other anti-inflammatory drugs.
  • cleft lip or palate patients.
  • patients with hypodontia, or hyperdontia.

研究组 & 干预措施

Olive Oil

Experimental

experimental group who will receive the local application of Olive Oil five times daily after teeth brushing

干预措施: Olive Oil Topical Oil (Drug)

结局指标

主要结局

The duration of orthodontic teeth aligning using Little irregualrity index

时间窗: 4 months

To detect the effect of local usage of Olive Oil on orthodontic brackets during the alignment phase of orthodontic treatment in changing the Little's irregularity in- dex.

次要结局

  • orthodontic wire surface roughness changes(one month)

研究者

发起方
Minia University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Nasef Abdelhameed

Lecturer of Orthodontics, Faculty of Dentistry, Minia University, Egypt

Minia University

研究点 (1)

Loading locations...

相似试验