A Prospective Randomized Controlled Trial of the Effect of Preoperative Prednisolone Administration on Thyroid Function in Patients with Graves' Disease

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适应症

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•Patients who have received sufficient information about the study, fully understand the study, and provide written informed consent of their own free will.
•Patients aged 18 years or older at the time of informed consent.
•Patients diagnosed with Graves' disease and scheduled to undergo total thyroidectomy.
•Patients who have difficulty taking antithyroid drugs.
•Patients receiving potassium iodide treatment continuously for at least 7 days.
•Patients with persistent hyperthyroidism approximately 2 weeks before the scheduled surgery and an FT3 level of 6 pg/mL or higher.
•Patients for whom at least 7 days of preoperative management can be secured before the scheduled surgery.

•Patients receiving continuous systemic corticosteroid therapy.
•Patients with a history of hypersensitivity to prednisolone.
•Patients with poorly controlled diabetes mellitus, active infection, severe psychiatric disease, or other conditions that may be exacerbated by corticosteroid administration.
•Patients with severe hepatic or renal dysfunction.
•Patients who develop thyroid storm before surgery and undergo surgery during its management.
•Patients for whom an adequate period of standard preoperative management cannot be secured, such as those requiring emergency surgery.
•Patients considered inappropriate for participation in this study by the principal investigator or a sub-investigator.

发起方

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