NCT03227003已完成不适用
Dietary Intake of One-carbon Metabolism Nutrients and DNA Methylation in Peripheral Blood
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5,983
- 主要终点
- Blood DNA methylation
研究概览
简要总结
The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays.
The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 27 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study
- •Completed a 121-item Food Frequency Questionnaire
- •Had a blood DNA sample with a measure of methylation
排除标准
- •Missing data in any of the outcome, exposure, or confounders (N=797 excluded)
结局指标
主要结局
Blood DNA methylation
时间窗: 2014-2015
Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay
次要结局
- Blood DNA methylation(2014-2015)
研究者
Roger Milne
Head, Cancer Epidemiology & Intelligence Division
Cancer Council Victoria
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