NCT03391154已完成3 期
Efficacy of Low Dose Levothyroxine During Pregnancy
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- 1st trimester miscarriage
研究概览
简要总结
the effect using low dose levo thyroxine in pregnant females with TSH level more than 2.5 mU/L in the first trimester on pregnancy outcome
详细描述
the study aim to detect the effect of low dose levothyroxine 50 ug on pregnant females and compare it with others receiving placebo
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •females with TSH more than 2.5 mU/L and less than 4 mU/L after biochemical diagnosis of pregnancy.
排除标准
- •associated endocrinopathies (PCO/ DM/ hyperprolactinemia )
- •associated medical condition (HTN/ chronic kidney disease.
- •history of recurrent pregnancy loss
研究组 & 干预措施
levothyroxine
Active Comparator
100 pregnant female with TSH of> 2.5 mU/L but less than 4 mU/L after biochemical diagnosis of pregnancy will receive 50 ug of levothyroxine (eltroxin 50) aspen,Egypt throughout the pregnancy
干预措施: levothyroxin (Drug)
结局指标
主要结局
1st trimester miscarriage
时间窗: during 1st 13 weeks of pregnancy
1st trimester spontaneous or missed abortion
次要结局
- adverse pregnancy outcome(last 26 week of gestation)
研究者
Radwa Rasheedy Ali
lecturer of obstetrics and gynecology
Ain Shams University
研究点 (1)
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