NCT06008717尚未招募不适用
A Prospective, Randomized Feasibility Clinical Trial Evaluating Bilateral Stimulation of the Dorsolateral Region of the Subthalamic Nucleus Receiving Hyperdirect (M1/SMA) Input in Subjects With Early-Stage Parkinson's Disease
Mallory Hacker0 个研究点目标入组 40 人开始时间: 2028年1月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- frequency and severity of adverse events
研究概览
简要总结
The goal of this trial is to evaluate the preliminary safety and efficacy of programming to maximize stimulation of the dorsolateral region of the subthalamic nucleus (STN) receiving primary motor (M1) and supplementary motor area (SMA), but not pre-SMA, input deep brain stimulation (DBS) in patients with early-stage Parkinson's disease (PD).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
motor scores will be blindly rated by an independent movement disorders neurologist who will be unaware of treatment assignment, ON vs OFF treatment status, or visit sequence
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A clinical diagnosis of idiopathic Parkinson's disease (PD). The diagnosis will be based upon the presence of at least two of the three cardinal motor signs of this disorder (akinesia/bradykinesia, rest tremor, and rigidity) with at least one of the signs being rest tremor or bradykinesia.
- •Clear and dramatic beneficial response to dopaminergic therapy, defined as ≥30% in UPDRS III with administration of the patient's medication during the screening neurological examination.
- •Hoehn and Yahr (H&Y) stage II when OFF medication.
- •No contraindications to surgery (i.e., subject does not have uncontrollable medical or psychiatric illness;
排除标准
- •Age between 50 and 75 years old.
- •Dopaminergic therapy for greater than one year and less than four years.
- •Available for follow-up for the entire duration of the study.
- •Informed Consent (Appendix C): The subject is willing and able to provide written informed consent.
- •MRI within normal range (Exclusion Criteria).
- •Subjects receiving antidepressant medication used specifically for the treatment of depression must be on stable doses for at least eight weeks prior to enrolling in the study.
- •Subjects must agree to maintain a stable regimen, if deemed medically appropriate by the treating physician, of any psychotropic medications throughout the blinded treatment phase.
- •Exclusion Criteria:
- •Evidence of an alternative diagnosis or secondary parkinsonism, as suggested by:
- •Features unusual early in the clinical course (e.g., prominent postural instability, freezing phenomena, or hallucinations unrelated to medications in the first 3 years after symptom onset)
- •Dementia preceding motor symptoms
- •Neurologic signs of upper motor neuron or cerebellar involvement
- •Significant orthostatic hypotension unrelated to medications
- •Unequivocal cortical sensory loss (i.e., graphesthesia, sterognosis with intact primary sensory modalities), clear limb ideomotor apraxia, or progressive aphasia
- •Vertical supranuclear gaze palsy, or selective slowing of vertical saccades
- •Unequivocal cerebellar abnormalities on examination, such as cerebellar gait, limb ataxia, or cerebellar oculomotor abnormalities (e.g., sustained gaze-evoked nystagmus, macro square wave jerks, hypermetric saccades)
- •Documentation of a condition known to produce parkinsonism and plausibly connected to the subject's symptoms (e.g., MRI scan with evidence of significant brain atrophy, lacunar infarcts, or iron deposits in the putamen; history of stroke, exposure to toxins, or encephalitis; or neuroleptic use within the past 6 months)
- •The expert evaluating physician, based on the full diagnostic assessment, believes that an alternative syndrome is more likely than PD.
- •Uncontrolled medical condition or clinically significant medical disease that would increase the risk of developing pre- or postoperative complications (e.g., significant cardiac or pulmonary disease, uncontrolled hypertension).
- •Dementia as evidenced by a Dementia Rating Score of less than
- •Diagnosis of probable behavioral variant frontotemporal dementia or primary progressive aphasia.
- •Currently active diagnosis of a major psychiatric disorder.
- •Previous brain operation or injury.
- •Active participation in another clinical trial for the treatment of PD.
- •Subjects with cardiac pacemakers or medical conditions that require repeat MRI scans.
- •Evidence of existing dyskinesia
- •Any current substance use disorder.
- •Any history of recurrent or unprovoked seizures.
- •Any prior movement disorder treatments that involved intracranial surgery or device implantation.
- •Any other active implanted intracranial device (e.g., cochlear implant) or implanted device to treat movement disorders (e.g., duodopa pump) whether turned on or off.
- •A condition requiring or likely to require the use of magnetic resonance imaging (MRI) or diathermy.
- •History of suicide attempt.
- •A female who is breastfeeding or of child-bearing potential with a positive urine pregnancy test or not using adequate contraception.
- •Inability or unwillingness of subject to give written informed consent.
- •Parkinsonian features restricted to the lower limbs for more than three years.
- •Treatment with a dopamine receptor blocker or a dopamine-depleting agent in a dose and time course consistent with drug-induced parkinsonism.
- •Normal functional neuroimaging of the presynaptic dopaminergic system, as measured by DaTSCAN.
- •Rapid progression of gait impairment requiring regular use of a wheelchair.
- •Early bulbar dysfunction, defined as one of severe dysphonia, dysarthria (speech unintelligible most of the time), or dysphagia (requiring soft food, nasogastric (NG) tube, or gastrostomy feeding).
- •Inspiratory respiratory dysfunction defined as either diurnal or nocturnal inspiratory stridor or frequent inspiratory sighs.
- •Recurrent (>1/year) falls because of impaired balance within 3 years of onset.
- •Otherwise unexplained pyramidal tract signs, defined as pyramidal weakness or clear pathologic hyperreflexia (excluding mild reflex asymmetry in the more affected limb and isolated extensor plantar response).
- •Bilateral symmetric parkinsonism throughout the disease course. The patient or caregiver reports bilateral symptom onset with no side predominance, and no side predominance is observed on objective examination.
研究组 & 干预措施
active subthalamic nucleus deep brain stimulation plus optimal drug therapy
Experimental
active subthalamic nucleus deep brain stimulation; plus optimal drug therapy
干预措施: active subthalamic nucleus deep brain stimulation plus optimal drug therapy (Device)
inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy
Active Comparator
inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy
干预措施: inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy (Device)
结局指标
主要结局
frequency and severity of adverse events
时间窗: 24 months
frequency and severity of adverse events
frequency and severity of adverse cognitive outcome
时间窗: 24 months
decline from baseline at ≥ 1.5 SD (modest) and ≥ 2.0 (substantial) in tests comprising a comprehensive neuropsychological battery
次要结局
- Stopped or Reversed Motor Progression(24 months)
研究者
Mallory Hacker
Assistant Professor of Neurology
Vanderbilt University Medical Center
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