Effect of pravastatin therapy on unruptured vertebral artery dissection: a randomized controlled exploratory study

Seoul National University Hospital0 个研究点目标入组 34 人开始时间: 待定最近更新: 2024年3月4日

适应症

试验速览

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•? Patients of korean nationality over 20 years old and under 75 years old
•? In the last 4 weeks, mildly and medically controlled symptoms occured, excluding hemorrhage and cerebral infarction of a moderate degree or severe, and unruptured vertebral artery dissection related to symptoms is radiologically identified
•? Vertebral artery dissection in V3 or V4 segments
•? Patients who agreed with this study

•? Vertebral artery dissection with hemorrhagic or moderate to severe ischemic cerebral infarction
•? Patients with diabetes or other vascular endothelial abnormalities
•? Patients who are currently taking statin or lipid lowering drugs for dyslipidemia or cardiovascular disease
•? Patients who had previous endovascular treatment or surgery or radiotherapy in or near the lesion
•? Patients with significant underlying disease or active infection or severe trauma
•? Patients with poor medication compliance
•? Patients with past history of pravastatin, aspirin-induced hypersensitivity and adverse events
•? Patients with galactose intolerance, lactose intolerance, Glucose-galactose malabsorption and genetic problem with paravastatin
•? severe liver failure(liver cirrhosis) or renal failure(eGFR < 30 ml/min/1.7 m2)
•? Patients with past history of myopathy including rhabdomyolysis
•? Women who are pregnant or possibly pregnant or who are lactating
•? Heavy drinker
•? Patients with hemophilia or with bleeding tendency or treated with peptic ulcer
•? Patients taking medication which is contraindication of comedication drugs with pravastatin, aspirin or has drug-drug interaction with pravastatin, aspirin

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