Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 332
- 试验地点
- 2
- 主要终点
- Number of participants who have either a myocardial infarction or cardiovascular death
研究概览
简要总结
Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause of death in patients following transplantation.
Current strategies to assess patient's cardiovascular risk prior to kidney transplantation do not identify those at highest risk and do not improve outcomes.
This study will use a heart scan known as computed tomography coronary angiography (CTCA) to see whether this scan can identify patients at highest risk of future cardiovascular disease prior to transplantation. Studies have shown it is able to do this in patients with normal kidney function.
The aim of this study is to develop CTCA as an effective tool to risk stratify patients prior to kidney transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Has kidney failure and is on the waitlist for a kidney transplant
- •Age 16 years and over
- •Able to give informed consent
排除标准
- •Contraindication to CT scanning, including contrast allergy
- •Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation
- •Inability to give informed consent
研究组 & 干预措施
Patients waitlisted for kidney transplantation
Patients who have been placed on the waiting list for a kidney transplant within Scotland
干预措施: Computed tomography coronary angiography (CTCA) (Radiation)
结局指标
主要结局
Number of participants who have either a myocardial infarction or cardiovascular death
时间窗: From time of CTCA scan to 36- and 60-months follow-up
The first event of myocardial infarction or cardiovascular death
次要结局
- Number of participants who are hospitalised due to any cardiovascular event(From time of CTCA scan to 36- and 60-months follow-up)
- Number of participants who die (all-cause death)(From time of CTCA scan to 36- and 60-months follow-up)
- Number of participants who have a cardiovascular death(From time of CTCA scan to 36- and 60-months follow-up)
- Number of participants who have a fatal or non-fatal myocardial infarction(From time of CTCA scan to 36- and 60-months follow-up)