NCT01251510已完成不适用
Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects
University Hospital, Gentofte, Copenhagen1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2010年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- GLP-1 secretion
研究概览
简要总结
PURPOSE
The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal fasting plasma glucose
- •Normal glucose tolerance
- •Normal haemoglobin levels
- •Informed content
- •Inclusion Criteria: (cholecystectomy group)
- •Laparoscopic cholecystectomy <6 months. Indication: Gallstones.
- •Normal fasting plasma glucose
- •Normal glucose tolerance
- •Normal haemoglobin levels
- •Informed content
排除标准
- •(both groups)
- •Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
- •1st degree relatives with diabetes
- •Obesity (BMI > 30)
- •Inflammatory bowels disease
- •Nephropathy
- •Liver disease
- •Medication which cannot be on hold for 24h
结局指标
主要结局
GLP-1 secretion
时间窗: Postprandial
次要结局
未报告次要终点
研究者
David P. Sonne
MD
University Hospital, Gentofte, Copenhagen
研究点 (1)
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