NCT07325864招募中不适用
Molecular Phenotyping of Primitive Lung Cancer and Metastatic Site
European Institute of Oncology1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2025年12月18日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- To investigate the molecular differences between primitive lung cancer and the metastatic site.
研究概览
简要总结
investigate the molecular differences between primitive lung cancer and the metastatic site.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged ≥18 years fit enough to tolerate the surgical operation;
- •the operative risk is considered low based on respiratory reserve and cardiac assessment;
- •the patient has clearly expressed willingness to adhere;
- •availability of pathological material for tumor DNA extraction and NGS execution.
排除标准
- •Women of childbearing age, pregnant or breastfeeding, or intending to become pregnant during the study.
- •Any other illness, metabolic disorder, physical examination, or laboratory findings that constitute a contraindication to study participation.
- •Recent or ongoing severe or clinically significant infection.
结局指标
主要结局
To investigate the molecular differences between primitive lung cancer and the metastatic site.
时间窗: From baseline to 18 months
Tumoral DNA will be extracted from the formalin-fixed paraffin-embedded (FFPE) block containing the highest percentage of tumor cells, with macrodissection, if necessary, to obtain at least 30% of tumor cells. DNA was extracted from FFPE samples. Next-generation sequencing (NGS) analysis will be performed as previously described. Gene amplification is defined by a coverage mean superior to 3SD.
次要结局
未报告次要终点
研究者
研究点 (1)
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