NCT04212884已完成不适用
Functional Decline and Quality of Life in People Aging with HIV in Asia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Functional disability
研究概览
简要总结
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people living with HIV (PLWH) in Asia.
详细描述
This research project is expected to have the following clinical impact
- To understand the impact of impaired functional status in PLWH in Asia would be important to determine the long-term health burden needs in this aging population in this part of the world.
- The identification of risk factors associated with impaired functional status would be important to guide clinical decisions in patient management, such as the choice of anti-retroviral regimen, and screening of and early intervention for modifiable risk factors. These are of paramount importance in the promotion of healthy aging in this population.
- This proposed cross-sectional study lays the foundation for the establishment of a longitudinal cohort for long-term follow up of people aging with HIV in Asia, with the objectives of evaluating the long-term impact of aging on clinical outcomes and functional status in PLWH in this region.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •HIV antibody positive
- •Age 35 years or above
- •Asian ethnicity, including but not limited to Chinese, Malay and Indian
排除标准
- •Inability or refusal to consent
- •Active infections requiring in-hospital treatment
结局指标
主要结局
Functional disability
时间窗: 24 months
Functional disability is defined as any difficulty in any of the six areas of functioning in daily life as assessed by WHO DAS II questionnaire
次要结局
- Cognitive decline(24 months)
- Frailty(24 months)
- Composite score for intrinsic capacity(24 months)
- Sarcopenia(24 months)
- Physical performance(24 months)
- Health-related quality of life(24 months)
研究者
Shui-Shan Lee, MD
Professor
Chinese University of Hong Kong
研究点 (1)
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