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临床试验/NCT00168220
NCT00168220撤回不适用

Predictors of Drug Hypersensitivity in HIV Infected Subjects

The Alfred1 个研究点 分布在 1 个国家开始时间: 2005年8月最近更新:
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适应症

试验速览

阶段
不适用
状态
撤回
发起方
试验地点
1
研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

A case-control study to look at hypersensitive and tolerant individuals matched for HLA genetic predisposition, when considering predictors of drug hypersensitivity.The study aims to identify the immunological factors increasing the risk of drug reactions in HIV positive individuals.

详细描述

  1. To determine in a case control study clinical parameters associated with drug HSR to abacavir, nevirapine and efavirenz in HIV infected subjects.
  2. To measure functional and numerical differences in DC populations and responses to TLR ligands in patients with HSR and tolerant subjects sharing genetic markers for susceptibility to HSR.
  3. Identify the role of different DC populations in the development of abacavir reaction by mixing and depletion studies in sensitized subjects and in in vitro assays for abacavir hypersensitivity.
  4. To measure T cell parameters including T cell viability in culture, and expression of fas and fasL on blood mononuclear cells in HIV infected controls and HSR patients.
  5. To measure blood T cell populations including drug reactive T cells and T regulatory cells in tolerant and reactive subjects with genetic susceptibility to Abacavir and Nevirapine HSR.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —（Adult, Older Adult）
性别
All
接受健康志愿者
否

入选标准

  • •HIV infected patients on treatment with the drugs Efavirenz, Nevirapine, or Abacavir.
  • •Age over 18 Cases are those who have had a hypersensitivity reaction, and controls are those who have had no reaction

排除标准

  • 未提供

研究者

发起方
The Alfred
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jennifer Hoy

Professor Jennifer Hoy

The Alfred

研究点 (1)

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