Comparison of the efficacy of steroid tapering over 4-weeks with 8-weeks in children with frequently relapsing or steroid dependent nephrotic syndrome on a steroid-sparing agent presenting with a relapse - A non-inferiority randomised controlled trial - nil

Jawaharlal Institute of Post Graduate Medical Education and research JIPMER0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年8月19日

试验速览

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•Children 1-18 years of age with frequently relapsing or steroid dependent nephrotic syndrome on a steroid-sparing agent (levamisole/ mycophenolate mofetil/calcineurin inhibitor) for the preceding 2 months
•Presenting with relapse

•Children currently on/have received oral cyclophosphamide in the preceding 6 months
•Children currently on/have received rituximab in the preceding 6 months
•Children who do not achieve remission even after 6 weeks of prednisolone treatment for the current relapse (late steroid resistance)
•Infantile onset nephrotic syndrome, monogenic and secondary forms of nephrotic syndrome (lupus nephritis, membranous nephropathy, etc.)
•Patients with significant comorbidities like diabetes (type 1 or drug induced), glaucoma, avascular necrosis of hip, psychosis, etc.
•Patient already enrolled in the study will not be re-enrolled in a future relapse

发起方

Jawaharlal Institute of Post Graduate Medical Education and research JIPMER