Phase 1 Study for Testing Efficacy of Cissus Verticillata L Infusion in Controlling Glucose Concentration
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- blood glucose
研究概览
简要总结
The purpose of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be effective in reducing glucose levels in blood and saliva of type 2 Diabetes patients.
详细描述
Type 2 diabetes mellitus is regarded as one of the most prevalent disease of the adult population. In many developing countries, this condition is regarded as major public health problem. Type 2 diabetes is a metabolic disorder characterized by high blood glucose related with a condition of insulin resistance and relative insulin deficiency. As Diabetes progresses, medications are necessary to control glucose levels.
The aim of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be as effective as a regular drug (glibenclamide) in reducing glucose levels in blood and saliva of type 2 Diabetes patients. Several medicinal plants have been used as potential medication for controlling glucose levels in Diabetes patients. Few studies have explored this effect related to Cissus verticillata L.infusion, though it has been indicated by folk medicine of some Latin American countries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •subjects of 30 up to 80 years of age
- •positive diagnostic for type 2 diabetes mellitus (blood glucose level above 126 mg/dL)
- •patients that signed the informed consent
排除标准
- •patients with renal and hepatic disfunction,
- •patients with cardiac problems or other systemic alterations (allergies, pulmonary and gastrointestinal problems)
- •pregnant women
研究组 & 干预措施
Glibenclamide
Patients used 5 mg glibenclamide daily for 60 days
干预措施: glibenclamide (Drug)
Experimental
Patients ingested the infusion of Cissus verticillata L. prepared as 1 g in 150 mL of hot water for 10 min. This was done daily for 60 days
干预措施: medicinal plant infusion (Other)
结局指标
主要结局
blood glucose
时间窗: 60 days
Blood glucose was measured using a Gluco Dr. Plus (AGM-3000) Blood Glucose Monitoring System.
次要结局
- Salivary glucose level(60 days)