Bone Marrow and Follicular Lymphoma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Flow cytometric quantification of cell populations
研究概览
简要总结
This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects.
Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis.
Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood.
To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples.
This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease.
This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Major patient
- •Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy
- •Patient with free, informed, written consent
- •Patient covered by a health insurance scheme
排除标准
- •History of haematological malignancy or haemogram disturbance
- •Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
- •Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)].
结局指标
主要结局
Flow cytometric quantification of cell populations
时间窗: 1 day
Bone marrow cell populations of lymphoma-free patients (lymphoid cells, myeloid cells, stromal cells and adventitial cells) will be quantified using a flow cytometry panel and compared with those of Follicular Lymphoma patients.
次要结局
未报告次要终点