Influence of Early SSC of Mothers and Their VLBW Infants on Maternal Sensitivity and Responsiveness, Attachment Patterns and Reactivity of HPA Axis. Molecular Characterization of SSC Influence on Stress Signaling Pathways.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Maternal sensitivity and responsiveness
研究概览
简要总结
The first hours after birth are a sensitive period for promotion of optimal mother-child-interaction and secure attachment. Maternal sensitivity and responsivness are high in the first hours after birth due to high oxytocin levels. Developing optimal mother-child-interaction is more difficult for preterm mothers because mother and child are separated after birth and the preterm infant is not able to show strong signs to promote maternal sensitivity. We hypothesize that promoting skin-to-skin contact of VLBW infants and their mothers for 60 minutes within the first hours after birth improves mother-child-interaction at 5 to 6 months corrected age. We also hypothesize that reactivity of HPA axis and molecular patterns of stress signaling pathways differ in preterm infant with or without SSC after birth.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 10 Minutes 至 60 Minutes(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Birthweight <1500g, first child, informed consent
排除标准
- •Multiples, malformation
研究组 & 干预措施
visual contact
After initial assessment/stabilization of the VLBW infant, visual contact of mother and infant is permitted for 5 minutes.
skin-to-skin contact
After initial stabilization mother and preterm infant are cared for skin-to-skin for 60 minuter. SSC is supervised by the attending neonatologist.
干预措施: skin-to.skin-contact (Procedure)
结局指标
主要结局
Maternal sensitivity and responsiveness
时间窗: 4 to 6 moinths corrected age
Maternal sensitivity and responsiveness are assessed with the "Mannheimer Method" for the analysis of mother child interaction. At the infants corrected age of 4 to 6 months a videotape of the mother changing the infants diapers and playing with the infant is used for analysis.
次要结局
- Reactivity of HPA-axis(36 to 40 weeks corrected age)
- Molecular characterization of stress signaling pathways(36 to 40 weeks corrected age)
研究者
Katrin Mehler
MD
University of Cologne
