A Cross-sectional Study on the Comparison of Serum SIRT-1 and MMP-9 Levels of Patients With Bronchiectasis and Healthy Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- MMP-9 and SIRT-1 levels (ng/mL) mesurment in the blood serum to compare between patient and control.
研究概览
简要总结
The purpose of this a cross-sectinol study is to measure the levels of MMP-9 and SIRT-1 levels in patients with bronchiectasis and healthy controls. The aim is to compare the serum levels of these molecules between patients and controls.
- Is the MMP-9 level increasing or decreasing?
- Is the SIRT-1 level increasing or decreasing in patients?
- Is the disease related to age and gender? Participants will only have one 5 ml blood sample drawn when they visit the chest illness clinic. Molecule levels will be measured in this blood's serum.
The patient group participants will be scanned once with high-resolution chest CT.
Apart from this, comparisons will be made using the age and gender information of the participants.
详细描述
In the overall study population of 60 subjects who applied to the Sivas Cumhuriyet University Faculty of Medicine Research and Practice Hospital Chest Diseases Clinic. The study population was selected regardless of age and gender. Participants selected bronchiectasis patients (n=30) who had symptoms (cough, sputum production) and had their diagnosis confirmed by a chest high-resolution CT scan within the previous year. The study excluded individuals with bronchiectasis not associated with cystic fibrosis and who had a worsening episode (according to the 2017 European Respiratory Society expert consensus criteria) (16) or had taken antibiotics during the previous four weeks. The study enrolled healthy controls (n=30) through advertisements who had acceptable chest X-ray and spirometry results and no lower airway symptoms or serious systemic disorders. The study eliminated individuals who were pregnant or nursing, as well as those with low comprehension. SIRT-1 and MMP-9 levels in the serum of the study group were determined by the ELISA method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Double (Participant, Investigator)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Bronchiectasis patients who were symptoms (cough, sputum production)
- •Individuals whose diagnosis was confirmed by a high-resolution chest CT scan taken within the previous year
排除标准
- •Individuals with bronchiectasis associated with cystic fibrosis and who had a worsening episode
- •individuals who were pregnant or nursing
- •those with low comprehension
- •taken antibiotics during the previous four weeks
结局指标
主要结局
MMP-9 and SIRT-1 levels (ng/mL) mesurment in the blood serum to compare between patient and control.
时间窗: not measured in time frame. general (1. day)
MMP-9 and SIRT-1 levels mesured in the blood serum. The most common side effect when blood is taken from the patient is slight bruising and swelling in the arm due to needle sticking. There will be no other serious side effects.
次要结局
未报告次要终点
研究者
Dilara Ulger Ozbek
principal investigator
Cumhuriyet University