Quantifying Blood Flow in the Aorta Using Phase-Contrast 4D Flow MRI - Phase 2
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 70
- 试验地点
- 1
研究概览
简要总结
This study aims to gain insights into aortic blood flow in healthy volunteers using PC 4D-flow MRI
详细描述
The goal of this observational study is to obtain PC 4D flow MRI scans in seventy healthy volunteers (without any known history of cardiovascular disease) to quantify local blood flow in the thoraco-abdominal aorta and its primary side branches and extract boundary conditions for future in-vitro and in-silico studies. Furthermore, the 3D geometry of the vessels within investigated FOVs, starting from ascending aorta to internal/external iliac arteries, will be obtained by performing a separate MRI sequence.
Participants will be asked to undergo MRI scans and are asked to fill out a questionnaire regarding their age, weight, height, and gender. By relating this data to the blood flow patterns observed in the aorta, conclusions can be drawn on the differences in blood flow with gender and how aortic blood flow changes with age.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy (in particular without any cardiovascular disease or history thereof) men or women
- •18 years of age or above;
- •BMI ≤ 30;
- •Willingness to undergo MRI scans;
- •Able to provide signed informed consent (IC)
排除标准
- •Irregular heartbeat.;
- •Any history of cardiovascular disease or current cardiovascular disease;
- •The standard MRI exclusion criteria (such as pacemakers, cerebral vascular clips, pregnancy, claustrophobia)
研究者
Marleen Krommendijk
Coordinating investigator
University of Twente