跳至主要内容
临床试验/CTRI/2026/03/105834
CTRI/2026/03/105834招募中不适用

Comparison of ascending aortic strain between hypertensives and healthy controls

Manipal Academy of Higher Education1 个研究点 分布在 1 个国家目标入组 189 人开始时间: 2026年3月23日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
189
试验地点
1
主要终点
Aortic strain

研究概览

简要总结

The study titled Comparison of ascending aortic strain between hypertensives and healthy controls using echocardiographic imaging is a single-center prospective observational study. The study aims to compare ascending aortic strain between hypertensive patients and healthy controls. The primary objective is to compare ascending aortic strain between hypertensive patients and healthy controls. The secondary objective is to examine the correlation between aortic strain and LV mass in hypertensive patients and to find the correlation between aortic strain and LV function parameters. 

Patients diagnosed with hypertension according to the 2025 AHA/ACC guidelines and healthy controls referred for an echocardiography will be screened based on inclusion and exclusion criteria. Healthy controls will include individuals who come for routine cardiac evaluation with no comorbidities. Study will be explained to the participants, and informed consent will be obtained. Demographic data will be documented from the case sheet. Echocardiographic parameters will be recorded and stored along with connected ECG. Initially, a few cases will be evaluated for inter-rater reliability between two investigators (a postgraduate student and an experienced sonographer) for echocardiographic parameters such as aortic strain, LV strain, LV mass, etc.

研究设计

研究类型
Observational

入排标准

年龄范围
30.00 Year(s) 至 50.00 Year(s)(—)
性别
All

入选标准

  • •Case group: Age-30 to 50 years, either gender, known case of hypertension with or without medication Control group: Age-30 to 50 years, either gender.

排除标准

  • •Coronary artery disease,
  • •Congenital heart disease,
  • •Cardiomyopathy,
  • •Cerebrovascular disease,
  • •Chronic kidney disease,
  • •Significant (more than mild) primary valvular disease,
  • •Poor echocardiographic window.

结局指标

主要结局

Aortic strain

时间窗: Baseline

LV mass

时间窗: Baseline

LV function

时间窗: Baseline

次要结局

未报告次要终点

研究者

申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Poojary Manasi Bhoja

Manipal College of Health Professions

研究点 (1)

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