Preliminary Study on the Changes of Perioperative Circulatory Function in Patients Undergoing Laparoscopic Radical Cystectomy for Bladder Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 186
- 试验地点
- 1
- 主要终点
- Brain Natriuretic Peptide(BNP)
研究概览
简要总结
To optimize the perioperative management of patients undergoing laparoscopic radical cystectomy(LPC) for bladder cancer through observation of perioperative changes of Brain Natriuretic Peptide(BNP), stroke volume variation(SVV), central venous pressure(CVP) and the use of transthoracic echocardiography(TTE).
详细描述
Long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer influence perioperative circulatory function, resulting in a series of pathophysiological changes. BNP is of high sensitivity and specificity in the evaluation of cardiac function. SVV and CVP are dynamic and static indices to predict fluid responsiveness. TTE is a good indicator of volume and cardiac function.Thus, we conducted the trial to assess the perioperative circulatory function in patients undergoing LPC. We hypothesized that long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer would increase perioperative blood volume and influence cardiac function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •undergoing laparoscopic radical cystectomy for bladder cancer
排除标准
- •Cardiac insufficiency
- •Hepatic insufficiency
- •Renal insufficiency
结局指标
主要结局
Brain Natriuretic Peptide(BNP)
时间窗: before induction (T1), at the end of operation(T2), at 12 hours (T3) and 24 hours (T4) postoperatively
To observe the change of BNP perioperatively.
Central Venous Pressure(CVP)
时间窗: before induction (T1),at the end of operation (T2), at 12 hours (T3) and 24 hours (T4) postoperatively
To observe the change of CVP perioperatively.
Stroke Volume Variation(SVV)
时间窗: before induction (T1), at the end of operation (T2)
To observe the change of SVV perioperatively.
Transthoracic Echocardiography
时间窗: before induction (T1),at the end of operation (T2), at 12 hours (T3) and 24 hours (T4) postoperatively
To observe the change of End-diastolic volume(EDV) perioperatively
次要结局
未报告次要终点
研究者
DAN HUANG
Principal Investigator, clinical attending in anesthesia department
RenJi Hospital