Characteristics of Culprit Lesion and Changes in Plaque Composition During Follow up in NSTEMI. A Dual Energy Cardiac CT Study
试验速览
- 阶段
- 不适用
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Description and characteristics of culprit lesion by DECT. (z-value)
研究概览
简要总结
Identifying patients who are at risk for a future myocardial infarction, is still one of the biggest challenges in cardiology.
In this study the investigators will investigate culprit lesion in patients with NSTEMI and the ability of cardiac CT with dual energy computed tomography (DECT) scanning to describe and identify plaques that may be vulnerable. The investigators will also describe changes in characteristic in both stable and unstable plaques during 1 year follow up of NSTEMI and a matching group of stable angina pectoris (SAP) patients.
详细描述
Patients with verified NSTEMI undergo contrast-enhanced coronary DECT before conventional coronary angiography (CAG), and DECT characteristics of the culprit lesion will be determined. All Non-culprit lesions will be observed during 2 month and 1 year follow up characteristics and changes in plaque composition, volume and core content will be assessed.
Patients with SAP undergo a baseline DECT similar to NSTEMI group. Because the expected change in coronary plaques in SAP group is minimal, there is no need for follow up at 2 month.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with NSTEMI and scheduled to CAG or patients with SAP
排除标准
- •Not suitable to undergo CT with contrast agent:
- •Known allergy-like reactions to contrast or Claustrophobia
- •Atrial fibrillation or significant arrhythmia judged to potentially limit quality of CT
- •Known renal failure/insufficiency or s-creatinin> 140 µmol/L.
- •Severe/symptomatic thyrotoxicosis
- •pacemaker
结局指标
主要结局
Description and characteristics of culprit lesion by DECT. (z-value)
时间窗: 72 hours
measure the z-value for the culprit lesion, by marking the culprit lesion with a region of interest (ROI) and the DECT will calculate the mean z-value by mg/mm\^3 in the marked ROI
次要结局
- Measure the volume of the culprit lesion(72 hours)
- Determine the mean Z value for non-culprit plaques containing 3: calcified tissue(1 year)
- z value in myocardium related to culprit vessel compared to z-value in myocardium corresponded to non-culprit vessel(72 hours)
- Determine the mean Z value for non-culprit plaques containing 1: soft tissue(1 year)
- changes in non-culprit plaques during 1 year in comparison til patients with stable angina pectoris(1 year)
- Determine the mean Z value for non-culprit plaques containing 2: mixed tissue(1 year)
- Describe if the culprit lesion contains 1: soft 2: mixed or 3: calcified tissue(72 hours)
- Measure the remodeling index of culprit lesion(72 hours)
研究者
Hussam Mahmoud Sheta
MD
Odense University Hospital