The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Continuing or Discontinuing on Aspirin: a Multicenter, Double-blind, Placebo-controlled, Randomized Clinical Trial - ASAPO

Medical Centre of Postgraduate Education, Poland0 个研究点目标入组 760 人开始时间: 2012年5月30日最近更新: 2014年6月10日

试验速览

暂无简介。

•Inclusion Criteria:
•1. Age 40 years or older
•2. Daily aspirin for primary or secondary prophylaxis
•3. Candidate for endoscopic polypectomy of at least one colorectal polyp 10mm or larger
•4. Signed written informed consent
•5. Written opinion from a cardiologist that the patient can cease taking aspirin for a period of 21 days in the peri-polypectomy period
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 760
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1. Polyposis syndrome
•2. Lifelong anticoagulant therapy with warfarin, acenocumarol, clopidogrel or ticlopidin
•3. Haemorrhagic diathesis
•4. Coagulation disorders INR > 1,5, APTT 2xnorm
•5. Coagulation disorders in family
•6. Heart failure (NYHA III-IV)
•7. Lung disease limiting activities of daily living

发起方

Medical Centre of Postgraduate Education, Poland