Effects of Acute Pain vs Context Change on Motor Learning Retention in Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Motor Retention Magnitude
研究概览
简要总结
To date, the effects of pain on motor learning have not been thoroughly investigated. When examining potential effects on retention of motor learning, it is important to dissociate any effects of pain from effects of a context change. The purpose of this research is to determine whether any altered retention of motor learning associated with acute pain is a true affect of pain or an affect of context (or both).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Application of pain or no stimulus cannot be masked from participants, nor from outcomes assessors.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-35 years old
- •Self-identifying as generally medically healthy
- •Able to read, write and speak English
- •Able to provide informed consent
- •Willing to undergo the experimental pain or non-painful electrical stimulation, if selected
排除标准
- •Resting HR < 50 or > 100 bpm
- •Resting BP < 90/60 or > 140/95 mmHg
- •Any history or current mental health condition, learning/developmental disability or cognitive impairment, including ADD/ADHD, severe anxiety, severe depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc.
- •Score on the MoCA <23
- •Score on the GAD-7 ≥ 10
- •Score on the PHQ-2 ≥ 2 and score on the PHQ-9 ≥ 10
- •Any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, endocrine, pulmonary, metabolic, psychiatric or neurological diagnosis
- •Any implanted electronic medical devices (i.e., cardiac pacemakers, cardiac defibrillators, spinal cord neurostimulators)
- •Any impaired sensation or weakness in either lower extremity or in the area targeted for the stimulus
- •History of serious concussion or head injury, defined as a loss of consciousness for > 5 minutes and/or requiring medical treatment, or > 2 concussions over the lifespan
- •Any history of acute or chronic problems with balance, any dizziness, or > 1 fall in the last 12 months
- •Taking 4 or more medications
- •Currently or regularly using any analgesic medications, over-the-counter remedies, or any other treatment for the purposes of pain relief (i.e., baby aspirin for heart health permitted, etc.)
- •Any current or chronic pain condition during the last year, located anywhere in the body
- •Allergy to capsaicin or hot peppers
- •Any skin lesion, breakage or irritation in the area targeted for the painful stimulus
- •Skin sensitivity to soaps/creams/perfumes or to heat
- •Poor circulation in the area targeted for the painful stimulus
- •Prior participation in a locomotor learning study in this lab within the last 2 years
结局指标
主要结局
Motor Retention Magnitude
时间窗: 24 hours post learning (day 2)
degree to which the learned locomotor pattern has been remembered (in step length percent change, normalized to the amount learned from day 1)
Motor Learning Magnitude
时间窗: immediately after learning (day 1)
degree to which the new locomotor pattern has been acquired (in step length percent change)
次要结局
未报告次要终点
研究者
Susanne M Morton
Associate Professor
University of Delaware