Early Mobilization in the ICU
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- presence of cognitive impairment
研究概览
简要总结
To study all ICU patients with an independent baseline functional status , who experience a critical illness requiring intubation and mechanical ventilation evaluating long-term cognitive and executive function and long term cost effectiveness in survivors who required mechanical ventilation.
详细描述
Immediate mobilization of mechanically ventilated (MV) ICU patients is not part of usual care in the U.S. or internationally. Our previous work supports that early mobilization through physical and occupational therapy for ICU patients on the ventilator can help them experience less delirium, spend less time in the ICU and hospital, and become more independent when they leave. To advance our knowledge in this area, large longitudinal studies are needed to understand the long-term physical, cognitive and mental health status of survivors and to test how specific ICU therapies may affect these outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intubated and MV > 24, < 96 hours
- •Baseline Barthel Index Functional Score > 70, functional at home
排除标准
- •Rapidly changing neurological conditions (e.g. stroke)
- •Cardiac arrest as cause for respiratory failure
- •Elevated intracranial pressure
- •Pregnancy (due to inability to provide continuous fetal monitoring)
- •Terminal condition (life expectancy < 6 months)
- •Traumatic brain injury, multiple limb fractures, pelvic fractures,
- •Severe chronic pain syndrome on admission
研究组 & 干预措施
Early physical therapy(PT) occupational therapy (OT)
Early PT OT assessments begin on first day of study. Therapy delivered by a team consisting of physical and occupational therapists and coordinated with daily sedative interruption
干预措施: early PT OT (Other)
standard care
PT OT delivered as ordered by the primary ICU team
结局指标
主要结局
presence of cognitive impairment
时间窗: up to 1 year post discharge
presence of cognitive impairment
时间窗: within the first 30 days after ICU admission
次要结局
- cognitive test score(up to 1 year post discharge)
- Insulin Resistance(day 3 of mechanical ventilation)
- institution free days(up to 1 yr post discharge)