Effects of ApoE4 Genotype Information and Intervention Intensity on the Fulfillment of Lifestyle Changes and Sensory Preferences
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 333
- 主要终点
- Health concern, scale 1-9
研究概览
简要总结
The study investigates whether information on having a risk genotype (ApoE4) and life style advisory information affects lifestyle changes and sensory preferences. The project studies also the ethic aspects of giving the information of risk genotype.
详细描述
We will run intervention based on our earlier pilot study. It includes intensive intervention and a modification of our earlier pilot intervention. Our intervention methods are general lectures of the effects of healthy diet (Finnish Nutrition Recommendations 2014) and healthy lifestyle for all participants. Effects on motivation, attitudes and preferences will be studied and verified by questionnaires and risk factors of cardiovascular disease and Alzheimer disease by analyzing clinical markers of lipid metabolism, general phenotype markers and profiles of nutritional markers. Nutritional biomarkers will verify also the self-reported changes of diet in the questionnaires and in digital food diaries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 40 and 60 years
- •overall good health (no chronic conditions e.g. mental disorders, cancer, liver or kidney disease, current or previous diagnosis),
- •body mass index (BMI) under 35 kg/m2,
- •blood pressure under 140/90 mmHg (medication allowed),
- •serum total cholesterol under 7.25 mmol/l (medication allowed)
- •fasting plasma glucose level under 7 mmol/l.
排除标准
- •Abnormal values of the alanine amino transferase, alkaline phosphatase, haptoglobin and thyroid stimulating hormone
结局指标
主要结局
Health concern, scale 1-9
时间窗: 2 years
1 not concerned at all
Waist circumference, cm
时间窗: 2 years
blood pressure, mmHg
时间窗: 2 years
Serum lipid peroxidation, MDA/µM
时间窗: 2 years
Serum Alkaline phosphatase, U/L
时间窗: 2 years
serum Fatty acids, g/100g fatty acids
时间窗: 2 years
Food involvement and Food mavenism, scale 1-5
时间窗: 2 years
5 fully agree
Number of participants with good quality of dietary fat
时间窗: 2 years
A questionnaire according to Finnish guidelines of Suomen Sydänliitto ry, Helldán \& Helakorpi, (2015)
Dietary habits, number of participants
时间窗: 2 years
A questionnaire asking for * Fish intake at least twice per week * Consumption of high fat and sugar foods * Consumption of vegetables * Alcohol consumption * Physical activity at least twice per week
Food choice questionnaire, health and taste attitude
时间窗: 2 years
Scale 1-7 (7 most important, fully agree)
Life-orientation test, scale 1-5
时间窗: 2 years
1 fully agree
height m
时间窗: 2 years
Visceral fat level (1-30)
时间窗: 2 years
Serum Sensitive C reactive protein, mg/L
时间窗: 2 years
Locus of Control, state-trait anxiety inventory, Three-Factor Eating Questionnaire (TFEQ) scale 1-4
时间窗: 2 years
4 fully agree
Serum lipid levels mmol/L
时间窗: 2 years
Blood glucose levels, mmol/L
时间窗: 2 years
weight kg
时间窗: 2 years
Serum Hemoglobin, g/L
时间窗: 2 years
Serum haptoglobin, g/L
时间窗: 2 years
Plasma thyrotropin, mU/L
时间窗: 2 years
serum APOE protein, mg/L
时间窗: 2 years
serum brain-derived neurotrophic factor, ng/ml
时间窗: 2 years
APOE and BDNF genotype
时间窗: baseline
Serum Alanine aminotransferase, U/L
时间窗: 2 years
serum Carotenoids, retinol and α-tocopherol, Plasma total phenolics ng/µl
时间窗: 2 years
Blood cell count
时间窗: 2 years
次要结局
- Body mass index(2 years)