Effect of Continuous High-frequency Oscillation (CHFO) and Continuous Positive Expiratory Pressure (CPEP) Therapy on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- To assess changes in systemic oxygenation
研究概览
简要总结
This single-center observational study aims to assess the effects of continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy on lung recruitment using electrical impedance tomography (EIT) in spontaneously breathing patients admitted to the intensive care unit.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who require pulmonary expansion and airway clearing as per clinical indication
- •Patients who provide valid informed consent according to local regulations
- •PaO2/FiO2 < 200 mmHg at inclusion
- •Patient on the Airway Care Score (ACS) < 7
排除标准
- •Refuse to participate
- •Age < 18 years
- •Hemodynamic instability, defined as systolic arterial pressure < 90 mmHg or mean pressure < 60 mmHg
- •Contraindication to using an EIT (i.e., pacemaker or defibrillator)
- •Inability to properly position the EIT device for anatomical reasons
结局指标
主要结局
To assess changes in systemic oxygenation
时间窗: Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment
Arterial partial pressure of oxygen (PaO2, mmHg) and PaO2/FiO2 ratio (mmHg)
Changes in lung recruitment using EIT
时间窗: Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment
Absolute reduction in the percentage (%) of lung volume collapse assessed with the electrical impedance tomography (EIT)
次要结局
- Mean arterial pressure, mmHg(Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment)
- Heart rate min-1(Immediately before starting treatment (PEP or CHFO), immediately after the end of treatment, at 30 minutes after the end of treatment and at 60 minutes after the end of treatment)
研究者
Lorenzo Ball
Prof.
University of Genova