Regional Haemodynamic Changes in Radial Artery Assessment With Continuous Pulsed-wave Doppler Ultrasound in Patients Undergoing Video-assisted Thoracic Surgery With Different Kinds of Anaesthesia Management
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- The Change of end-diastolic velocity
研究概览
简要总结
The objective of the trial was to evaluate velocity-associated parameters of pulsed-wave Doppler ultrasound at induction, discharge from the post-anaesthesia care unit and during inspiratory cough in addition to the consumption of phenylephrine during the operation in patients undergoing video-assisted thoracic surgery with three types of anaesthesia management.
详细描述
The objective of the trial was to evaluate velocity-associated parameters of pulsed-wave Doppler ultrasound at induction, discharge from the post-anaesthesia care unit and during inspiratory cough in addition to the consumption of phenylephrine during the operation in patients undergoing video-assisted thoracic surgery with three types of anaesthesia management. The patients in this trial were visited during the entire operation and just before leaving the post-anaesthesia care unit. Velocity-associated data related to pulsed-wave Doppler ultrasound and the consumption of phenylephrine were collected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ethnic Chinese;
- •age, 18 to 65 years old;
- •American Society of Anaesthesiologists (ASA) physical status I or II;
- •required VATS for lung surgery and one lung ventilation .
排除标准
- •body mass index exceeding 30 kg/m2; Patients with a history of hypertension, diabetes mellitus or arteriosclerosis; and any allergy to drugs used in the study.
- •Patients with arrhythmias or implanted cardiac pacemakers were excluded. Patients with diseases of the central or peripheral nervous system were excluded.
- •Patients taking medications affecting the autonomic nervous system, such as b-blockers and calcium channel blockers
研究组 & 干预措施
Group control
In the control group, local anaesthesia at the incision was induced by 0.5% ropivacaine by the surgeon just before the surgery.
干预措施: 0.5% ropivacaine local anaesthesia (Drug)
Paravertebral Block Group
In Group Paravertebral Block, patients received standardized general anaesthesia supplemented by paravertebral Block. The USG approach for TPVB was used with the patient in the lateral position at the T4-T6 level according to the incision protocol in our centre.
干预措施: 0.5% ropivacaine paravertebral block (Drug)
Epidural Block Group
The investigators designed a study to assess whether there were any blood flow indexes change during induction with doppler ultrasonography ;general anesthesia combined with epidural block
干预措施: 0.25% ropivacaine epidural block (Drug)
结局指标
主要结局
The Change of end-diastolic velocity
时间窗: baseline and 10 minutes after induction
The primary outcome was the end-diastolic velocity at 12 time points of anaesthesia induction among the three groups.
次要结局
- pulsed-wave Doppler ultrasound(before leaving the PACU, up to 5 minutes)
- intraoperative consumption of phenylephrine(through study completion, an average of 3 hours)
研究者
Wen-fei Tan
Associate proffesor
China Medical University, China