Evaluation of Commiphora Myrrh Versus Sodium Hypochlorite as Root Canal Irrigant on Post- Operative Pain and Bacterial Load Reduction in Symptomatic Mandibular Premolar Teeth With Necrotic Pulp. (A Randomized Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 42
- 主要终点
- Post-operative pain
研究概览
简要总结
Clinically compare the post-operative pain , incidences post-operative swelling , post-operative number of analgesic tablets taken by patient and amount of bacterial load reduction after using 50% Commiphora Myrrh Chemomechanical preparation , versus 2.5% NaOCl,in asymptomatic necrotic mandibular premolar treated in single visit.
详细描述
The patients will be randomly divided into 2 groups. Intervention group (50% Commiphora Myrrh solution root canal irrigant) and control group (2.5% sodium hypochlorite root canal irrigant)
Post-operative pain will be measured at 6,12,24,48 hours post-operatively The pain will be recorded using numerical rating scale
Post-operative swelling will be measured at 6,12,24,48 hours post-operatively The swelling will be receded using visual swelling rating scale
Number of analgesic tablets taken by the patient post-operatively. Up to 48 hours
Amount of bacteria load reduction The intracanal bacterial load reduction will be determined using agar culture technique by counting the colony forming units per milliliter (CFI /ml) before and after root canal preparation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy patient (ASA I, II).
- •Age between 20 and 40 years.
- •Male or female.
- •Patient who is able to sign and comprehend the pain scale (committed patient).
- •Mandibular single rooted premolars having the following criteria:
- •With single root canal.
- •Diagnosed clinically with pulp necrosis.
- •Absence of spontaneous pulpal pain.
- •Positive pain on percussion denoting apical periodontitis.
- •Slight widening of periodontal space or peri-apical radiolucency smaller than 3 mm (0-2mm)
排除标准
- •Medically compromised patients (ASA III or IV).
- •Teeth with:
- •Patients who could not interpret the NRS.
- •Immature roots.
- •Vital pulp tissues.
- •Association with swelling.
- •Acute peri-apical abscess or acute exacerbation of a chronic abscess.
- •Mobility Grade II or III.
- •Previously accessed or endodontically treated.
- •Deep periodontal pockets more than 4 mm.
- •Vertical root fractures, coronal perforation, calcification, and external or internal root resorptions.
- •Patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women will be also excluded.
- •History of intolerance to NSAIDs.
研究组 & 干预措施
Commiphora Myrrh
50% Commiphora Myrrh
干预措施: Root canal irrigant Commiphora Myrrh 50% (Other)
Sodium hypochlorite
2.5% NaOCl
干预措施: Root canal irrigant Commiphora Myrrh 50% (Other)
结局指标
主要结局
Post-operative pain
时间窗: Post-operative pain measured at 6,12,24,48 hours after single visit Treatment
Categorical None 0 Mild 1-3 Moderate 4-6 Sever 7-10
次要结局
- incidence of Post-operative swelling(Up to 48 hours post-)
研究者
Rahaf Abdullah khalel manzalawi
Principal investigator
Cairo University