Comparative Clinical and Biochemical Study Evaluating the Effect of Proton Pump I Nhibitors Versus Histamine 2 Receptor Antagonists as an Adjuvant With Chemotherapy in Patients With Non-hodgkin Lymphoma.
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Number of patients eith radiological and clinical improvement
研究概览
简要总结
The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump I nhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma.
详细描述
The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump Inhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma to compare the difference in efficacy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DLBCL Lymphoma subtype --No comorbid disease
排除标准
- •Pregnancy
- •Peptic ulcer
- •Severe cardiac disease
- •Osteoporosis
研究组 & 干预措施
CHOP
CHOP only
干预措施: CHOP (Drug)
CHOP Plus Lanzoprazole
CHOP Plus Lanzoprazole 60 mg
干预措施: CHOP Plus Lanzoprazole (Drug)
CHOP Plus Famotidine
CHOP Plus Famotidine 40 mg
干预措施: CHOP Plus Famotidine (Drug)
结局指标
主要结局
Number of patients eith radiological and clinical improvement
时间窗: 6 months
Number of patients eith radiological and clinical improvement after cycles of chemotherapy
次要结局
未报告次要终点
研究者
Sherief Abd-Elsalam
PhDTropical Medicine
Tanta University