The Association Between Plasma DPP4 Activity And Prognosis of Patients With ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 625
- 主要终点
- major adverse cardiac or cerebrovascular events
研究概览
简要总结
Increased plasma DPP4 activity (DPP4a) could predict both subclinical and new-onset atherosclerosis, and our previous study has found that the DPP4a was significantly lower in MI patients compared with patients having chest pain or unstable angina alone, and DPP4a is associated with no-reflow and major bleeding events in STEMI patients during hospital stay. As no-reflow phenomenon and major bleeding events independently associates with a worse in-hospital and long-term prognosis. One may speculate that the DPP4a is associated with long-term follow-up adverse cardiovascular events in these patients.The hypothesis was tested in this study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •consecutive patients of acute STEMI come to our department,absent of cardiogenic shock, and survival for at least 24 h after PCI treatment.
排除标准
- •patients with cancer, and patients who were taking a DPP4 inhibitoror a glucagon-like peptide-1 (GLP-1) analogue
结局指标
主要结局
major adverse cardiac or cerebrovascular events
时间窗: The median follow-up was 30 months
including cardiovascular death, non-fatal myocardial infarction, heart failure and stroke
次要结局
- repeated revascularization(The median follow-up was 30 months)
- non-cardiovascular death(The median follow-up was 30 months)
- stroke(The median follow-up was 30 months)
研究者
Li Jing Wei
MD, Dr.
Chinese PLA General Hospital