The Role of MRI Perfusion to Detect Locally Recurrent or Persistent Disease in Prostate Carcinoma Treated With Radiation Therapy - A Pilot Study
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- To determine whether there may be a role for MRI perfusion in the detection of recurrent or persistent prostatic cancer after previous radiotherapy
研究概览
简要总结
This is a pilot study of 50 patients to establish whether there is a potential role for MRI perfusion in the detection of locally recurrent or persistent prostate carcinoma after previous treatment with radiotherapy. All subjects will be patients who have had localised prostate cancer treated with radiotherapy and have already agreed to undergo a biopsy of the prostate to look at local control within the prostate as part of their management. The objective of the study is to establish whether there is a relationship between recurrent or persistent disease within the prostate and increased perfusion on MRI at these sites.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Previously have had radical radiotherapy for localised prostate cancer
- •Due to undergo routine post-treatment prostatic biopsies
- •Suitable for MRI scan
- •Adequate renal function
- •No previous reaction to gadolinium
- •Able to give informed consent
- •No recent prostate biopsy within 6 weeks of enrolment
- •Performance status (Eastern Cooperative Oncology Group [ECOG]) 0 or 1
排除标准
- •Not suitable for MRI scan
- •Previous reaction to gadolinium
- •Impaired renal function
- •Inability to give informed consent
结局指标
主要结局
To determine whether there may be a role for MRI perfusion in the detection of recurrent or persistent prostatic cancer after previous radiotherapy
次要结局
未报告次要终点