Verticality Perception - Dissociating Head and Trunk Contributors in Healthy Human Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions
研究概览
简要总结
The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ages 18-60 years
- •informed consent
- •absence of
排除标准
- •Exclusion Criteria:
- •peripheral-vestibular deficit
- •disturbed consciousness
- •history of sensory deficits
- •visual field deficits
- •other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •intake of antidepressants, sedatives, or neuroleptics
- •pregnancy, unless excluded by a negative pregnancy test
- •known neck pain or status post neck trauma
研究组 & 干预措施
Vestibular stimulation
This is the experimental paradigm applied in all participants
干预措施: Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk) (Other)
Vestibular stimulation
This is the experimental paradigm applied in all participants
干预措施: 3D-video-head impulse testing (Other)
Vestibular stimulation
This is the experimental paradigm applied in all participants
干预措施: Vestibular-evoked myogenic potentials (VEMPs) (Other)
结局指标
主要结局
Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions
时间窗: During the turntable measurement (90 minutes)
次要结局
- relative contribution of head- and trunk-based sensory systems based on Bayesian modelling(while on the turntable (1.5 hours))