NCT07701733招募中不适用
ARISE: Assessing Lung Cancer Risk in Never-Smoking Women
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 7
- 主要终点
- Identify factors associated with the risk of NSCLC
研究概览
简要总结
The researchers are doing this study to learn more about factors that may increase the risk of lung cancer in people who have never smoked. This information may help predict which people who have never smoked may be more likely to get lung cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Female at birth
- •Age 40-74 years
- •No smoking history
- •Participants must be never-smokers, defined as having smoked <100 cigarettes in their lifetime
- •Documentation of disease - case patients
- •o Case patients must have pathologically confirmed primary lung adenocarcinoma. New and prevalent cases will be eligible. Case patients with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.
- •Criteria for control participants
- •Control participants must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules. Participants recruited as controls and found on imaging to have lesions suspicious for lung cancer will be excluded from analysis and followed prospectively. Data regarding these participants will be reported in a sensitivity analysis. Additional control participants will be recruited to ensure balanced age- and race-matched enrollment by frequency matching. Control participants with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.
排除标准
- 未提供
研究组 & 干预措施
Case patients
Must have pathologically confirmed primary lung adenocarcinoma.
干预措施: Questionnaire (Other)
Control participants
Must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules.
干预措施: Questionnaire (Other)
结局指标
主要结局
Identify factors associated with the risk of NSCLC
时间窗: 3 years
analyses will include all participants who completed the demographic and exposure assessment and whole-exome sequencing
次要结局
未报告次要终点
研究者
研究点 (7)
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