Categorization of Wilms Tumors by Genetic Expression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 600
- 试验地点
- 2
- 主要终点
- New molecular categories of Wilms tumor identified and measured by gene expression profiles
研究概览
简要总结
This laboratory study is using gene expression profiling to identify different categories of Wilms tumors. Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
详细描述
OBJECTIVES:
I. Identify new molecular categories of Wilms tumor (WT) based on the gene expression profiles of samples from patients with this disease.
II. Develop a classifying system (classifier) that will predict a defined number of clinically relevant categories based on expression of an established set of genes.
III. Confirm and test the classifier with further analysis of the genes by several different methodologies, using additional patient samples that are outside of the case/cohort but which possess the clinically or scientifically relevant parameter.
IV. Validate the use of the classifier to predict defined groups within a second set of samples (for which investigators are blinded to the clinical and biological data) by subsequent comparison with true incidence of pertinent markers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Specimens from patients previously enrolled as "On Study" or "Followed Biology Only" on protocol NWTSG-5 (COG-Q9401)
- •Study follow-up data for disease status available
- •National Wilms Tumor Study Group/Children's Oncology Group pathology review showing "favorable" histology
- •Sufficient biology samples available without using biology bank reserves
排除标准
- 未提供
结局指标
主要结局
New molecular categories of Wilms tumor identified and measured by gene expression profiles
时间窗: Up to 6 years
Identification of genes that as a whole provide strong prediction of outcomes of interest
时间窗: Up to 6 years
Supervised methods such as CART or Shrunken Centroid Classifier will be used.
次要结局
未报告次要终点