Denosumab and male infertility: a randomized double-blinded intervention study

Dpt. of Growth and Reproduction0 个研究点目标入组 90 人开始时间: 2016年9月16日最近更新: 2018年2月5日

适应症

试验速览

暂无简介。

•Men > 18 years of age refered due to infertility in need for further investigation with
•Sperm count > 0,05 mio./ml.
•The men have either sperm count <15 mio./ml or
•<40 % motile spermatozoer (A) or
•<4 % morphological normale spermatozoer (strict criteria)
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 95
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Men with chronic diseases (diabetes mellitus, thyroid disease, endocrine diseases requirering treatment, malignant diseases or diseases known to be affected by- or interfere with vitamin D supplements (granulomatous diseases such as sarcoidosis, tuberculosis, wegeners, vasculitis as well as inflammatory bowel diseases e.g. chron’s disease or ulcerative colitis etc).
•Men with active or previous malignant disease
•Any case with indication for tesis biopsy,
•Serum ionized calcium < 1,15 mmol/l
•Total calcium < 2.14 mmol/l
•Poor dental status og dental implants
•Men with obstructive oligospermia or who has been vasectomized
•Serum Inhibin B < 30 pg/ml
•Abnormal karyotype

发起方

Dpt. of Growth and Reproduction