NCT03114904已完成不适用
Comparison of the Efficacy of a Protocol for the Withdrawal of Neurosedation From the Usual Strategy in Cerebroses: Randomized Controlled Trial.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- A variation of the Jasinski score between H0 (stop sedation) and H6. This score measures the signs of withdrawal
研究概览
简要总结
The withdrawal syndrome in benzodiazepines and morphine is common in intensive care, the incidence is estimated at 32.1%.
Cerebrospatized patients are probably more prone to withdrawal because they require high doses of sedation.
Moreover, this syndrome is probably deleterious on the cerebral hemodynamics (high point of the therapeutic management).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major Patient
- •Admitted in Neuroreanimation
- •Cerebroséé (TC-HSA-AVC)
- •Mono or multi failing
- •After a neurosedation ≥ 3 days by hypnotic type benzodiazepine (Midazolam®) and morphinomimetic (Sufentanyl®) in IVSE
- •Affiliation to Social Security
- •Agreement of the person of confidence
排除标准
- •Addiction to opiates, cocaine or cannabis
- •Neurological Pathology Before Hospitalization
- •Patient suffering from cardiac arrest
- •Pregnant woman
- •Sedation window
- •Patient under tutelage or curatorship or deprived of public law
研究组 & 干预措施
"Usual" weaning management
Other
干预措施: Variation of Jasinski score between H0 (stop of sedatives) and H6 (Other)
Introduction to H2 for the discontinuation of therapeutics
Other
干预措施: Variation of Jasinski score between H0 (stop of sedatives) and H6 (Other)
结局指标
主要结局
A variation of the Jasinski score between H0 (stop sedation) and H6. This score measures the signs of withdrawal
时间窗: 3 months
次要结局
未报告次要终点
研究者
研究点 (1)
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