Evaluation of a Novel Blood Test Hypercoagulability in Surgical Patients With Metastatic Carcinoma: A Pilot Study

OBJECTIVES:

Primary

• Determine whether whole blood thrombin generation assay (WBTGA) detects hypercoagulability in patients with metastatic carcinoma compared with a healthy control group.
• Determine whether results of the WBTGA will change as a result of major surgery performed on patients with metastatic carcinoma.
• Establish a reference interval for the WBTGA using healthy controls.

Secondary

• Compare a battery of plasma components known to affect or reflect coagulant or fibrinolytic reactions in patients with metastatic carcinoma vs healthy controls.
• Establish reference intervals for this battery of tests using healthy controls.
• Determine how major surgery in cancer patients affects this battery of factors.
• Identify changes in these factors that correlate with changes in the WBTGA.
• Compare the results of WBTGA tests in patients who develop venous thromboembolism (VTE) with those who do not.