Transfusion Prediction Model in Orthotopic Liver Transplantation Based on Thromboelastometry: Prospective Validation Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Red blood cell transfusion
研究概览
简要总结
Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation. In a post-hoc analysis from a randomized study recently conducted by our group, presurgical values of MA10 Extem < 35 mm are highly predictive of RBC administration , with no further improvement over MA10 Extem >40 mm ; suggesting that MA10 Extem between 35-40 would be the optimal range to manage blood product administration. The aim of the study is to validate this result in a prospective cohort of patients submitted to ortothopic liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presurgical hemoglobin < 13 d/L and clot firmness at 10 minutes Extem < 35 mm
排除标准
- •Previous thrombosis
- •Antithrombotic treatment
- •No consent
研究组 & 干预措施
Prospective cohort
Fibrinogen and/or platelet administration
干预措施: Fibrinogen and/or platelets administration (Other)
结局指标
主要结局
Red blood cell transfusion
时间窗: until 24h after liver transplant
次要结局
- Thrombosis(28 days after liver transplant)
研究者
Annabel Blasi
Anesthesiologist
Hospital Clinic of Barcelona