Evaluation of the Efficacy of Cryotherapy Combined With Intralesional Hepatitis B Virus Vaccine Versus Either Therapy in the Treatment of Multiple Cutaneous Warts :a Comparative Study

Introduction:

Warts are common, benign and epithelial proliferations and growths affecting the skin and/or the mucosa (Sterling JC,et al.,2014) caused by human papilloma virus (HPV) which is a double stranded DNA virus with a worldwide distribution(Pérez-González et al., 2022).

There are approximately 218 types of HPV identified as causing infections in humans (Magalhães et al., 2021).

Infection occurs predominantly via direct contact, although skin lesions can be transmitted indirectly, via contaminated surfaces, Abrasions and microtraumas expose the basal layer keratinocytes and facilitate contagion (EgawaN,et al 2015 and Vlahovic T.C.et al,2016).

The clinical manifestations of HPV-related diseases vary depending upon the HPV type and the site of inoculation (Burlamaqui et al., 2017).Extragenital cutaneous warts can present as common warts, plane warts, plantar warts (Abeck D. et al, 2019).HPV infection is one of the most common sexually transmitted infections with the most common manifestation of HPV in the genital area is anogenital warts or condylomata acuminate (Gofur, 2022). Infections due to these viruses may result in a wide spectrum of clinical manifestations in the skin and mucosa(Cubie, 2013).