NCT00598013已完成不适用
A Randomized Controlled Trial of Pioglitazone on Insulin Resistance, Insulin Secretion and Atherosclerosis in Renal Allograft Recipients Without History of Diabetes
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 83
- 试验地点
- 1
- 主要终点
- Insulin Resistance and Insulin Secretion
研究概览
简要总结
The aim of this study was to evaluate the effect of pioglitazone treatment on insulin secretion, insulin resistance, and progression of atherosclerosis in renal allograft recipients without preoperative history of diabetes.
详细描述
This is a prospective, randomized, open-label study. The pioglitazone treatment group received 30mg pioglitazone at 2 weeks after renal transplantation for 12 months.
After treatment, we estimated insulin sensitivity index for transplantation,first phase and second phase insulin secretion, secretion area under the curve,and carotid intima-media thickness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Renal allograft recipients were eligible to participate in the study if they were aged ≥ 18 years, had no previous history of organ transplantation and were not currently using steroids or other immunosuppressants.
排除标准
- •Diabetes before transplantation
- •Severe metabolic or infectious disease
- •Hepatic disease
- •Congestive heart failure (New York Heart Association II-IV)
- •Cadaver donor kidney donor transplantation
- •Unstable condition of the transplanted kidney
研究组 & 干预措施
1
Experimental
干预措施: Pioglitazone (Drug)
结局指标
主要结局
Insulin Resistance and Insulin Secretion
时间窗: 1 year
次要结局
- carotid intima-media thickness(1 year)
研究者
研究点 (1)
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