Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 340
- 试验地点
- 1
研究概览
简要总结
It is well known that 'globus sensation in throat' is caused by the chronic irritation and inflammation of oral, pharyngeal, or laryngeal mucosa, such as laryngopharyngeal reflux and chronic postnasal drip.
Xerostomia and pharyngoxerosis due to salivary hypofunction also proved to induce the mucosal change of the oral cavity and pharynx.
However, no previous studies have documented the prevalence of salivary hypofunction in patients with globus pharyngeus.
Through this clinical investigation, we hypothesized that the salivary hypofunction might be one of the leading cause of globus pharyngeus.
详细描述
Subjects: patients with symptoms of globus pharyngeus
Globus symptom scoring: 0(mild) to 5(severe)
Subjective symptom analysis by "Standard Table for Xerostomia and Pharyngoxerosis"
Subjective physical finding analysis by "Standard Table for Xerostomia and Pharyngoxerosis"
Objective analysis of Salivary function by 99m-Tc Salivary scintigraphy
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with globus pharyngeus symptoms
排除标准
- •Subjects with tumors in oral cavity, oropharynx, nasopharynx, hypopharynx, which may cause globus symptoms
- •subjects, who do not undergo the endoscopic exam for the upper aerodigestive tract including oral cavity, oropharynx, nasopharynx, hypopharynx.
- •subjects, who take medications that may have potential effect on the mucosa of the upper aerodigestive tract including oral cavity, oropharynx, nasopharynx, hypopharynx.
- •subjects with poor medical performance (<70%)