NCT01696786已完成不适用
Oocyte Cryopreservation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Pregnancy rate following thawing/warming of oocytes
研究概览
简要总结
The specific aim of this study is to further develop methods of oocyte cryopreservation and evaluate their impact on reproductive outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 42 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Any consenting female who wishes to freeze unfertilized oocytes and are:
- •at risk for ovarian hyperstimulation syndrome (enlarged ovaries with abdominal fluid accumulation) and postponement of pregnancy has been recommended.
- •a cancer patient anticipating treatment and have been cleared by the oncologists for ovarian stimulation.
- •a female who seeks to preserve her future fertility and does not wish to use donor or partner sperm to fertilize her eggs.
- •a donor egg recipient who elects to have some of the eggs obtained fertilized with husband/partner sperm and the rest cryopreserved for future use.
- •a patient for whom the partner's sperm retrieval or production has failed and donor sperm is not an option.
- •a patient who, for religious or ethical reasons, wants to limit the number of fresh oocytes exposed to sperm (fertilization) and do not want to either discard or donate the excess oocytes.
- •has been clinically and psychologically approved for ovarian stimulation
- •age between 12 and 42 years, inclusive, at time of informed consent.
- •willing and able to comply with the protocol.
- •willing to provide follow-up information from her OB/GYN of any CVS/amniocentesis results, as well as information on obstetrical outcome.
- •agree to undergo intracytoplasmic sperm injection (ICSI) when oocytes are thawed.
- •For cancer patients:
- •No significant ovarian pathology as judged by physical exam and radiological studies;
- •Patient's general condition and prognosis deemed favorable for surgery and chemo/radio therapy;
- •No other major medical illness,
- •Oncologist approval for the ovarian stimulation and egg retrieval.
排除标准
- •Age > 42 Subjects who do not meet the inclusion criteria will be ineligible for participation in this study.
结局指标
主要结局
Pregnancy rate following thawing/warming of oocytes
时间窗: 1 year
Pregnancy rate following thawing/warming of oocytes
Implantation rate per embryo transferred
时间窗: 1 year
Implantation rate per embryo transferred
Survival rate of cryopreserved oocytes with each cryopreservation method
时间窗: 1 year
Survival rate of cryopreserved oocytes with each cryopreservation method
次要结局
未报告次要终点
研究者
研究点 (1)
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