An intervention study of optimizing algorism-based pharmacological treatment for schizophrenia - An intervention study of optimizing algorism-based pharmacological treatment for schizophrenia

Department of Neuropsychiatry Keio University School of Medicine0 个研究点目标入组 200 人开始时间: 2011年1月22日最近更新: 2023年10月17日

适应症

试验速览

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•1.We exclude patients are in remission status, and showing mild or milder symptoms in all 8 subscales on PANSS. Treatment-resistant cases: We exclude patients receive several antipsychotics (more than chlorpromazine-conversion dosage of 2000mg/ day during at least last 6 months, or taken more than 7 types of antipsychotics), but show a score less than 30 on FACT-SZ (definitely requiring hospitalization level). 2.Patients did not show any sufficient response to more than two kinds of atypical antipsychotics, or patients have intolerability to atypical antipsychotics so far. 3.Patients have severe underlying diseases, such as diabetes, substance dependence at present, serious physical disease, possibility of pregnancy, severe intellectual disorder, and organic brain disorder. 4.Patients show comorbid personality disorders diagnosed by DSM-IV. 5.Patients have high probability of attempting suicide. 6.Patients show an allergic reaction to a medication or have a history of the allergy. 7.Patients do not agree to participate in the study on a written informed consent form. 8.Patients are not able to receive examination and assessments for pharmaceutical therapy on designated date.

发起方

Department of Neuropsychiatry Keio University School of Medicine